Vignesh was born in Chennai and moved to Bangalore at the age of 10, where he stayed until his 12^th grade. He then travelled to the US to pursue his undergraduate studies at the University of Minnesota, Twin Cities. There, he worked in the laboratory of Prof. Thomas R. Hoye. While at UMN, he worked on trapping hexadehydro-Diels–Alder (HDDA) generated benzynes with sulfur- and nitrogen-based nucleophiles. In 2016, he began his graduate studies at UC Berkeley under the supervision of Prof. Richmond Sarpong. While at UC Berkeley, Vignesh developed a unified synthetic route to access two structurally related natural products, delavatine A and incarviatone A. He was also part of a team that accomplished the first total synthesis of a Calyciphylling B-type alkaloid, daphlongamine H. After his graduation, he moved to the East Coast to pursue postdoctoral studies in the laboratory of Prof. Alison E. Wendlandt at the Massachusetts Institute of Technology. While at MIT, Vignesh primarily focused on developing catalytic tools to effect contra-thermodynamic transformations. In October 2023, Vignesh began his independent career at IISc, where his group will work on methodology-driven total synthesis projects and develop new skeletal editing tools.